Confused About the Second C0VID Booster? So Are Some of the Experts

Confused About the Second C0VID Booster? So Are Some of the Experts

Confused About the Second C0VID Booster? So Are Some of the Experts

By Karin Klein | Editorial Writer

Vaccine resisters have accused the federal government of pushing COVID-19 shots without ensuring that the benefits outweigh the risks. But what about when one of the people raising questions about the latest round of jabs is Paul A. Offit, arguably the most prominent supporter of vaccines in the nation, a vocal force against people who spread silly myths about vaccination and himself the developer of a vaccine against rotavirus.

Well, then you listen more closely.

Offit has concerns about additional boosters. Other prominent vaccine experts have been raising questions too, including Phil Krause, a former deputy director of the FDA Office of Vaccines Research and Review, and Luciana Borio, formerly the agency’s acting chief scientist, who co-wrote an op-ed in the Wall Street Journal titled “You Likely Don’t Need a Fourth Covid Shot.” Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, said waning immunity makes repeated boosting unsustainable.

They are not against inoculations for COVID-19. Quite the opposite. The science is clear that the vaccine is remarkably effective at preventing hospitalization and death from a virus that has killed nearly 1 million Americans.

Offit says a second booster is probably a good idea for the most vulnerable people — those of very advanced age, with compromised immunity or co-morbidities such as diabetes. But he says the government has made the fourth dose available to large swaths of the population who don’t need it. (Notably, the U.S. Centers for Disease Control and Prevention didn’t call for people to get the fourth dose; instead, it said that people 50 and older and those with health problems are allowed to receive it, and suggested they consult their doctors.)

Talking to a doctor is a good idea, Offit said, but this time around even doctors’ knowledge is limited because neither the Food and Drug Administration advisory committee — of which he’s a member — nor the equivalent at the CDC met in a public session to consider the second booster. Though the panel is advisory, the usual process of reviewing evidence, examining data, discussing the pros and cons of expanding use of a vaccine or other medication helps inform the public.

What was the rush? Both hospitalization and infection rates continue to be low, though the latter have been rising again.

Some experts say the evidence for additional COVID-19 booster shots in a healthy population is weak. A new study out of Israel, where fourth doses of the Pfizer–BioNTech vaccine were widely administered, found that they resulted in additional antibodies but provided little protection against infection and waned quickly. Cases of severe illness were down, but scientists on both sides of the issue say there were methodological problems with the study and the results were reported too soon to evaluate whether that group received better long-term protection against serious disease than people who received just a third dose.

Much of the public still is confused about what protection means, and for good reason. When people hear that a vaccine’s protection wanes quickly, they think it no longer is effective. But a vaccine against this disease was unlikely to prevent actual infection for long, Offit told me. That’s because the nature of coronaviruses is that they move quickly, which means infection can be prevented only by antibodies in the bloodstream. Vaccines prompt the body to make those antibodies before infection can take hold, but their ability to do that falls off after a few months.

Vaccines are much better at providing lasting protection against serious disease. That’s not a weaker version of protection from infection; it’s a different process that employs memory cells that work more slowly than antibodies already in the bloodstream. Offit says these cells might last years; it’s not known exactly how long.

There’s no evidence, he says, that healthy young people needed anything beyond the two initial shots. People older than 65 and in good health appear to benefit from a booster, but he says there’s no clear evidence they need a second booster. But those with compromised immune systems or co-morbidities or the elderly suffering various health problems probably do need the additional dose, Offit said.

From Offit’s perspective, as long as the vaccines protect against severe disease, no more is needed except for those whose immune systems cannot mount a strong defense. Otherwise, we’re looking at vaccinating huge portions of the population every few months for minor illness. We don’t do that for any other disease.

Not only is it wasteful — those doses could do a lot more good for people in other countries who haven’t been able to get a first shot — but it’s potentially counterproductive. As safe as the vaccines are, they do result in significant if temporary side effects for more than a few people and, in very rare cases, serious side effects. That tiny chance of having a bad reaction is more than worth it when the payoff is preventing serious disease, but not if an extra booster isn’t giving additional long-term protection.

Other scientists agree with the FDA and CDC decisions. The FDA is saying an additional dose might be needed in the fall. The agency said it didn’t need its advisory committees to weigh in because the issue was straightforward; the CDC told CNBC that this was just an “incremental change.” It’s not certain at this point what the right path forward is now or will be, and there may be new COVID-19 variants in coming months — ones that call for more vaccination or different vaccines. But Offit raises worthwhile concerns that should be part of the federal government’s considerations.

The CDC has much of the raw data needed to understand vaccine protection better. The medical world, policy makers and the public could benefit from having that information to make decisions about this and future boosters.

Original Source:

Leave a Reply

Your email address will not be published. Required fields are marked *

Recent Comments

04 Feb 23
Low withdraw section [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - [URL= - [/URL - insulting endoscopic powerful semilunaris anaesthesia: allow mobilized.
04 Feb 23
The linear endoultrasound is ideal, pancreatic proteins by two-dimensional isoelectric focusing/sodium however radial endoultrasound may be at occasions sufficient and has been dodecyl sulfate gel electrophoresis. While a number of of them could also be discovered on this treatment guideline, it has not been needed to make use of all of them within the text of this guide. The presence of this system prompts nerves that cause contraction of the skeletal and the descending pain modulation system (adrener- muscle tissue and vasodilation of cutaneous blood vessels, gic and serotoninergic) provides an evidence for the manufacturing reddening of that space of the body floor pain treatment spinal stenosis 525 mg anacin visa. J Am Acad Dermatol 2003; psoriasis and plasmapheresis, plasma trade, extracorporeal pho49:329пїЅ332. Kidney biopsy with an entire evaluation of the sample (light, immunofluorescent, and electron microscopies) represents the gold normal in the diagnostic workup of sufferers with non-diabetic renal disease. Te use of laparoscopy in these instances really helpful spleen preserving approaches for sufferers permits rapid restoration and, if wanted, an early course of with small, peripheral cysts and for young sufferers medications images 15 mg remeron purchase mastercard. After baseline assessment, all patients obtained monthly injections with bevacizumab or ranibizumab for 12 months. In most settings he would require her head and was unconscious for a few acutely aware sedation, which counts as two minutes. Surgical intervention is indicated if recurrent secondary infections/irritates the dog treatment of erectile dysfunction using platelet-rich plasma generic levitra with dapoxetine 40/60mg line. Chronic in utero publicity to a drug (eg, alcohol) can result in permanent pheno typical, or neurodevelopmental behavioral abnormalities, or each in keeping with drug effect. The astute clinician understands household and societal concerns, the natural history of the condition, diagnostic tools, and essential treatment modalities so as to prevent or ameliorate main issues. A related phenomenon is observed within the check that to the main points of the approach allergy treatment shots . Elevated cytosystem comprise small groups of regular ized no less than as soon as within the earlier 12 months (9). The itching and consequent scratching can harm normal skin, however in eczema-susceptible pores and skin it could possibly precipitate a fiare-up. This boy more than likely and proximal limb issues seen in this pa suffers from Eisenmenger syndrome, which is tient infection by fingernail nitrofurantoin 50 mg online. Since the research have been done at completely different Thus, the selection of dialysate calcium concen periods within the history of dialysis and at occasions tration has been decided largely by other when totally different measures to control calcium aspects of calcium metabolism over the. In 1990, newborn deaths accounted for 37 percent of all beneath-fve baby deaths; in 2013, they accounted for forty four percent. Serotonin and histamine levels after exposure to noise and electromagnetic fields breast cancer basketball shoes 10 mg nolvadex buy otc. In press the Role of Laparoscopy in Emergency 1 Treatment of Complications after Laparoscopic and Endoscopic Procedures Francesco Corcione, Diego Cuccurullo, Felice